2021 American Athletic Conference Leaders Passing Defense - Games in December/January Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 1 | 37 | 14 | 37.8 | 171 | 4.6 | 0 | 0 | 76.66 | 37.0 | 171.0 |
| 2 | Navy | 1 | 16 | 7 | 43.8 | 108 | 6.8 | 0 | 0 | 100.45 | 16.0 | 108.0 |
| 3 | Houston | 2 | 54 | 30 | 55.6 | 417 | 7.7 | 4 | 0 | 144.86 | 27.0 | 208.5 |
| 4 | Cincinnati | 2 | 54 | 34 | 63.0 | 431 | 8.0 | 5 | 2 | 153.14 | 27.0 | 215.5 |
| 5 | Tulsa | 1 | 28 | 19 | 67.9 | 176 | 6.3 | 0 | 1 | 113.52 | 28.0 | 176.0 |