2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Houston | 8 | 10 | 165 | 1 | 1.25 |
| 2 | Cincinnati | 5 | 9 | 83 | 0 | 1.80 |
| 3 | East Carolina | 5 | 7 | 100 | 1 | 1.40 |
| 3 | UCF | 8 | 7 | 83 | 0 | 0.88 |
| 5 | South Florida | 3 | 5 | 88 | 0 | 1.67 |
| 5 | SMU | 7 | 5 | 52 | 0 | 0.71 |
| 5 | Tulsa | 7 | 5 | 44 | 0 | 0.71 |
| 8 | Memphis | 4 | 2 | 14 | 0 | 0.50 |
| 8 | Temple | 6 | 2 | 7 | 1 | 0.33 |
| 10 | Tulane | 2 | 1 | 33 | 0 | 0.50 |
| 10 | Navy | 2 | 1 | 0 | 0 | 0.50 |