2021 American Athletic Conference Leaders Interceptions - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 11 | 15 | 174 | 1 | 1.36 |
| 2 | Houston | 13 | 14 | 210 | 2 | 1.08 |
| 3 | East Carolina | 10 | 13 | 147 | 2 | 1.30 |
| 4 | UCF | 12 | 11 | 114 | 0 | 0.92 |
| 5 | SMU | 10 | 10 | 120 | 0 | 1.00 |
| 6 | South Florida | 8 | 8 | 161 | 1 | 1.00 |
| 7 | Tulane | 8 | 7 | 123 | 1 | 0.88 |
| 7 | Tulsa | 9 | 7 | 60 | 0 | 0.78 |
| 7 | Memphis | 11 | 7 | 16 | 0 | 0.64 |
| 10 | Navy | 9 | 6 | 22 | 0 | 0.67 |
| 10 | Temple | 10 | 6 | 56 | 1 | 0.60 |