2021 American Athletic Conference Leaders Interceptions - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 13 | 16 | 201 | 1 | 1.23 |
| 2 | East Carolina | 11 | 14 | 124 | 1 | 1.27 |
| 2 | Houston | 13 | 14 | 210 | 2 | 1.08 |
| 4 | Tulsa | 12 | 11 | 115 | 1 | 0.92 |
| 5 | South Florida | 11 | 10 | 249 | 1 | 0.91 |
| 5 | UCF | 12 | 10 | 114 | 0 | 0.83 |
| 7 | Tulane | 11 | 8 | 95 | 0 | 0.73 |
| 7 | Memphis | 11 | 8 | 40 | 0 | 0.73 |
| 9 | SMU | 11 | 7 | 63 | 0 | 0.64 |
| 9 | Navy | 12 | 7 | 23 | 0 | 0.58 |
| 11 | Temple | 11 | 5 | 52 | 1 | 0.45 |