2021 American Athletic Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Cincinnati | 5 | 8 | 138 | 1 | 1.60 |
| 2 | East Carolina | 4 | 7 | 102 | 1 | 1.75 |
| 3 | South Florida | 4 | 5 | 73 | 1 | 1.25 |
| 3 | Navy | 5 | 5 | 1 | 0 | 1.00 |
| 5 | Houston | 4 | 4 | 45 | 1 | 1.00 |
| 5 | UCF | 5 | 4 | 81 | 0 | 0.80 |
| 7 | Tulsa | 4 | 3 | 44 | 0 | 0.75 |
| 8 | Tulane | 4 | 1 | 33 | 0 | 0.25 |
| 8 | Memphis | 4 | 1 | 0 | 0 | 0.25 |
| 8 | Temple | 4 | 1 | -7 | 0 | 0.25 |
| 8 | SMU | 4 | 1 | -8 | 0 | 0.25 |