2021 Big Ten Conference Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Nebraska | 5 | 4 | 26 | 30 | 6.00 |
| 2 | Ohio State | 4 | 1 | 23 | 24 | 6.00 |
| 3 | Indiana | 5 | 4 | 19 | 23 | 4.60 |
| 4 | Purdue | 4 | 5 | 13 | 18 | 4.50 |
| 4 | Michigan | 4 | 3 | 15 | 18 | 4.50 |
| 6 | Penn State | 5 | 4 | 12 | 16 | 3.20 |
| 7 | Wisconsin | 3 | 1 | 13 | 14 | 4.67 |
| 7 | Rutgers | 4 | 1 | 13 | 14 | 3.50 |
| 9 | Maryland | 4 | 1 | 11 | 12 | 3.00 |
| 10 | Michigan State | 3 | 3 | 8 | 11 | 3.67 |
| 11 | Iowa | 2 | 3 | 4 | 7 | 3.50 |
| 12 | Northwestern | 3 | 0 | 6 | 6 | 2.00 |
| 13 | Minnesota | 2 | 1 | 3 | 4 | 2.00 |
| 14 | Illinois | 1 | 1 | 0 | 1 | 1.00 |