2021 Big Ten Conference Leaders Passes Defended - Games in November Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Ohio State | 4 | 2 | 21 | 23 | 5.75 |
| 2 | Wisconsin | 4 | 10 | 11 | 21 | 5.25 |
| 2 | Iowa | 4 | 6 | 15 | 21 | 5.25 |
| 4 | Penn State | 4 | 3 | 14 | 17 | 4.25 |
| 5 | Nebraska | 3 | 2 | 14 | 16 | 5.33 |
| 5 | Purdue | 4 | 3 | 13 | 16 | 4.00 |
| 5 | Maryland | 4 | 2 | 14 | 16 | 4.00 |
| 5 | Michigan State | 4 | 2 | 14 | 16 | 4.00 |
| 5 | Michigan | 4 | 1 | 15 | 16 | 4.00 |
| 10 | Rutgers | 4 | 3 | 12 | 15 | 3.75 |
| 11 | Indiana | 4 | 1 | 13 | 14 | 3.50 |
| 12 | Illinois | 3 | 4 | 8 | 12 | 4.00 |
| 12 | Northwestern | 4 | 2 | 10 | 12 | 3.00 |
| 14 | Minnesota | 4 | 3 | 8 | 11 | 2.75 |