2021 Big Ten Conference Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Ohio State | 4 | 4 | 26 | 30 | 7.50 |
| 2 | Iowa | 4 | 6 | 21 | 27 | 6.75 |
| 3 | Illinois | 5 | 3 | 23 | 26 | 5.20 |
| 4 | Maryland | 4 | 4 | 18 | 22 | 5.50 |
| 4 | Michigan State | 4 | 4 | 18 | 22 | 5.50 |
| 4 | Michigan | 4 | 1 | 21 | 22 | 5.50 |
| 7 | Penn State | 4 | 5 | 16 | 21 | 5.25 |
| 7 | Nebraska | 5 | 5 | 16 | 21 | 4.20 |
| 9 | Purdue | 4 | 2 | 17 | 19 | 4.75 |
| 10 | Rutgers | 4 | 3 | 15 | 18 | 4.50 |
| 11 | Indiana | 4 | 1 | 16 | 17 | 4.25 |
| 12 | Minnesota | 4 | 3 | 13 | 16 | 4.00 |
| 12 | Northwestern | 4 | 3 | 13 | 16 | 4.00 |
| 14 | Wisconsin | 3 | 1 | 9 | 10 | 3.33 |