2021 Big Ten Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Ohio State | 2 | 4 | 12 | 16 | 8.00 |
| 2 | Minnesota | 2 | 2 | 9 | 11 | 5.50 |
| 2 | Indiana | 2 | 1 | 10 | 11 | 5.50 |
| 2 | Michigan | 2 | 1 | 10 | 11 | 5.50 |
| 5 | Iowa | 2 | 0 | 9 | 9 | 4.50 |
| 5 | Wisconsin | 3 | 1 | 8 | 9 | 3.00 |
| 7 | Nebraska | 1 | 1 | 7 | 8 | 8.00 |
| 7 | Illinois | 2 | 1 | 7 | 8 | 4.00 |
| 7 | Purdue | 2 | 1 | 7 | 8 | 4.00 |
| 10 | Rutgers | 1 | 2 | 4 | 6 | 6.00 |
| 10 | Michigan State | 1 | 0 | 6 | 6 | 6.00 |
| 12 | Penn State | 1 | 2 | 2 | 4 | 4.00 |
| 12 | Maryland | 1 | 0 | 4 | 4 | 4.00 |
| 14 | Northwestern | 1 | 2 | 1 | 3 | 3.00 |