2022 Big 12 Conference Leaders Passes Defended - Games in August/September Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 4 | 17 | 21 | 7.00 |
| 1 | Oklahoma | 4 | 3 | 18 | 21 | 5.25 |
| 1 | Baylor | 4 | 2 | 19 | 21 | 5.25 |
| 4 | Kansas State | 4 | 7 | 12 | 19 | 4.75 |
| 5 | Iowa State | 4 | 4 | 12 | 16 | 4.00 |
| 6 | Oklahoma State | 3 | 1 | 14 | 15 | 5.00 |
| 6 | Kansas | 4 | 3 | 12 | 15 | 3.75 |
| 8 | Texas Tech | 4 | 2 | 12 | 14 | 3.50 |
| 8 | Texas | 4 | 2 | 12 | 14 | 3.50 |
| 10 | West Virginia | 4 | 1 | 11 | 12 | 3.00 |