2022 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | TCU | 13 | 12 | 62 | 74 | 5.69 |
| 2 | Oklahoma | 11 | 15 | 43 | 58 | 5.27 |
| 3 | Texas | 11 | 8 | 46 | 54 | 4.91 |
| 4 | Oklahoma State | 11 | 12 | 40 | 52 | 4.73 |
| 5 | Kansas | 11 | 10 | 39 | 49 | 4.45 |
| 6 | Baylor | 9 | 13 | 34 | 47 | 5.22 |
| 6 | Kansas State | 12 | 13 | 34 | 47 | 3.92 |
| 8 | Texas Tech | 11 | 9 | 31 | 40 | 3.64 |
| 9 | West Virginia | 11 | 4 | 30 | 34 | 3.09 |
| 10 | Iowa State | 10 | 4 | 24 | 28 | 2.80 |