2021 Atlantic Coast Conference Leaders Total Defense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 13 | 1252 | 2719 | 894 | 3971 | 4.44 | 305.5 |
| 2 | Syracuse | 12 | 1513 | 2451 | 776 | 3964 | 5.11 | 330.3 |
| 3 | North Carolina State | 12 | 1479 | 2491 | 804 | 3970 | 4.94 | 330.8 |
| 4 | Boston College | 12 | 2043 | 2082 | 760 | 4125 | 5.43 | 343.8 |
| 5 | Pittsburgh | 14 | 1249 | 3700 | 978 | 4949 | 5.06 | 353.5 |
| 6 | Florida State | 12 | 1735 | 2798 | 874 | 4533 | 5.19 | 377.8 |
| 7 | Miami (Florida) | 12 | 1668 | 3007 | 865 | 4675 | 5.40 | 389.6 |
| 8 | Virginia Tech | 13 | 2198 | 2914 | 873 | 5112 | 5.86 | 393.2 |
| 9 | Louisville | 13 | 2037 | 3180 | 898 | 5217 | 5.81 | 401.3 |
| 10 | Wake Forest | 14 | 2738 | 3049 | 988 | 5787 | 5.86 | 413.4 |
| 11 | North Carolina | 13 | 2340 | 3094 | 889 | 5434 | 6.11 | 418.0 |
| 12 | Georgia Tech | 12 | 2184 | 3276 | 826 | 5460 | 6.61 | 455.0 |
| 13 | Virginia | 12 | 2710 | 2882 | 844 | 5592 | 6.63 | 466.0 |
| 14 | Duke | 12 | 2470 | 3741 | 873 | 6211 | 7.11 | 517.6 |