2021 Atlantic Coast Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 9 | 785 | 1674 | 580 | 2459 | 4.24 | 273.2 |
| 2 | Syracuse | 8 | 1082 | 1411 | 508 | 2493 | 4.91 | 311.6 |
| 3 | Boston College | 9 | 1505 | 1388 | 548 | 2893 | 5.28 | 321.4 |
| 4 | North Carolina State | 10 | 1260 | 2090 | 664 | 3350 | 5.05 | 335.0 |
| 5 | Miami (Florida) | 8 | 1149 | 1563 | 573 | 2712 | 4.73 | 339.0 |
| 6 | Florida State | 8 | 1171 | 1670 | 572 | 2841 | 4.97 | 355.1 |
| 7 | Pittsburgh | 11 | 947 | 2982 | 745 | 3929 | 5.27 | 357.2 |
| 8 | Louisville | 8 | 1141 | 1789 | 546 | 2930 | 5.37 | 366.3 |
| 9 | North Carolina | 9 | 1619 | 1873 | 595 | 3492 | 5.87 | 388.0 |
| 10 | Virginia Tech | 11 | 1810 | 2490 | 723 | 4300 | 5.95 | 390.9 |
| 11 | Wake Forest | 11 | 2219 | 2158 | 765 | 4377 | 5.72 | 397.9 |
| 12 | Virginia | 8 | 1704 | 1749 | 546 | 3453 | 6.32 | 431.6 |
| 13 | Georgia Tech | 8 | 1425 | 2194 | 572 | 3619 | 6.33 | 452.4 |
| 14 | Duke | 10 | 1984 | 2914 | 704 | 4898 | 6.96 | 489.8 |