2021 Atlantic Coast Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 8 | 1122 | 1585 | 543 | 2707 | 4.99 | 338.4 |
| 2 | Clemson | 8 | 940 | 1965 | 592 | 2905 | 4.91 | 363.1 |
| 3 | Pittsburgh | 9 | 755 | 2524 | 630 | 3279 | 5.20 | 364.3 |
| 4 | Syracuse | 8 | 1172 | 1747 | 527 | 2919 | 5.54 | 364.9 |
| 5 | Boston College | 8 | 1651 | 1320 | 522 | 2971 | 5.69 | 371.4 |
| 6 | Louisville | 8 | 1032 | 2058 | 577 | 3090 | 5.36 | 386.3 |
| 7 | Florida State | 8 | 1311 | 1843 | 589 | 3154 | 5.35 | 394.3 |
| 8 | Miami (Florida) | 8 | 1172 | 2024 | 580 | 3196 | 5.51 | 399.5 |
| 9 | Virginia Tech | 8 | 1406 | 1865 | 556 | 3271 | 5.88 | 408.9 |
| 10 | North Carolina | 9 | 1362 | 2439 | 625 | 3801 | 6.08 | 422.3 |
| 11 | Wake Forest | 10 | 1925 | 2383 | 696 | 4308 | 6.19 | 430.8 |
| 12 | Virginia | 8 | 1866 | 2049 | 575 | 3915 | 6.81 | 489.4 |
| 13 | Georgia Tech | 8 | 1445 | 2472 | 594 | 3917 | 6.59 | 489.6 |
| 14 | Duke | 8 | 1747 | 2778 | 591 | 4525 | 7.66 | 565.6 |