2021 Atlantic Coast Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 7 | 928 | 1407 | 498 | 2335 | 4.69 | 333.6 |
| 2 | Pittsburgh | 7 | 597 | 1756 | 503 | 2353 | 4.68 | 336.1 |
| 3 | North Carolina State | 5 | 356 | 1336 | 366 | 1692 | 4.62 | 338.4 |
| 4 | Boston College | 6 | 1267 | 884 | 381 | 2151 | 5.65 | 358.5 |
| 5 | Syracuse | 5 | 900 | 1042 | 304 | 1942 | 6.39 | 388.4 |
| 6 | Florida State | 5 | 951 | 1017 | 383 | 1968 | 5.14 | 393.6 |
| 7 | Virginia Tech | 6 | 928 | 1539 | 369 | 2467 | 6.69 | 411.2 |
| 8 | Miami (Florida) | 5 | 665 | 1458 | 373 | 2123 | 5.69 | 424.6 |
| 9 | North Carolina | 6 | 1193 | 1367 | 394 | 2560 | 6.50 | 426.7 |
| 10 | Wake Forest | 8 | 1918 | 1629 | 581 | 3547 | 6.10 | 443.4 |
| 11 | Louisville | 6 | 954 | 1784 | 432 | 2738 | 6.34 | 456.3 |
| 12 | Georgia Tech | 6 | 1044 | 1811 | 439 | 2855 | 6.50 | 475.8 |
| 13 | Duke | 5 | 1012 | 1696 | 361 | 2708 | 7.50 | 541.6 |
| 14 | Virginia | 5 | 1348 | 1469 | 362 | 2817 | 7.78 | 563.4 |