2022 Atlantic Coast Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Clemson | 2 | 3 | 14 | 17 | 8.50 |
| 1 | Louisville | 4 | 3 | 14 | 17 | 4.25 |
| 3 | Wake Forest | 2 | 4 | 10 | 14 | 7.00 |
| 4 | Duke | 2 | 1 | 11 | 12 | 6.00 |
| 5 | North Carolina State | 2 | 2 | 8 | 10 | 5.00 |
| 6 | Florida State | 1 | 0 | 9 | 9 | 9.00 |
| 6 | Virginia Tech | 2 | 0 | 9 | 9 | 4.50 |
| 8 | Boston College | 2 | 0 | 8 | 8 | 4.00 |
| 8 | North Carolina | 3 | 1 | 7 | 8 | 2.67 |
| 10 | Pittsburgh | 1 | 3 | 3 | 6 | 6.00 |
| 10 | Virginia | 1 | 0 | 6 | 6 | 6.00 |
| 10 | Miami (Florida) | 2 | 2 | 4 | 6 | 3.00 |
| 13 | Georgia Tech | 1 | 1 | 3 | 4 | 4.00 |
| 14 | Syracuse | 2 | 1 | 2 | 3 | 1.50 |