2021 American Athletic Conference Leaders Passing Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 247 | 135 | 54.7 | 1392 | 5.6 | 10 | 7 | 109.69 | 30.9 | 174.0 |
| 2 | Navy | 10 | 272 | 181 | 66.5 | 2305 | 8.5 | 13 | 6 | 149.08 | 27.2 | 230.5 |
| 3 | Tulsa | 5 | 150 | 90 | 60.0 | 1191 | 7.9 | 8 | 6 | 136.30 | 30.0 | 238.2 |
| 4 | Temple | 5 | 145 | 95 | 65.5 | 1222 | 8.4 | 15 | 3 | 166.32 | 29.0 | 244.4 |
| 5 | Memphis | 7 | 246 | 161 | 65.4 | 1718 | 7.0 | 11 | 6 | 134.00 | 35.1 | 245.4 |
| 6 | Houston | 5 | 154 | 95 | 61.7 | 1262 | 8.2 | 10 | 4 | 146.77 | 30.8 | 252.4 |
| 7 | UCF | 4 | 152 | 97 | 63.8 | 1012 | 6.7 | 7 | 3 | 131.00 | 38.0 | 253.0 |
| 8 | East Carolina | 6 | 183 | 116 | 63.4 | 1581 | 8.6 | 8 | 7 | 142.74 | 30.5 | 263.5 |
| 9 | South Florida | 8 | 261 | 177 | 67.8 | 2115 | 8.1 | 18 | 5 | 154.82 | 32.6 | 264.4 |
| 10 | Tulane | 9 | 297 | 204 | 68.7 | 2561 | 8.6 | 22 | 7 | 160.85 | 33.0 | 284.6 |
| 11 | SMU | 4 | 138 | 86 | 62.3 | 1160 | 8.4 | 11 | 2 | 156.33 | 34.5 | 290.0 |