2021 American Athletic Conference Leaders Passing Defense - Games Lost Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Temple | 9 | 222 | 139 | 62.6 | 1603 | 7.2 | 20 | 4 | 149.40 | 24.7 | 178.1 |
| 2 | Cincinnati | 1 | 28 | 17 | 60.7 | 181 | 6.5 | 3 | 1 | 143.23 | 28.0 | 181.0 |
| 3 | Tulsa | 6 | 143 | 92 | 64.3 | 1204 | 8.4 | 8 | 4 | 147.94 | 23.8 | 200.7 |
| 4 | Houston | 2 | 41 | 28 | 68.3 | 421 | 10.3 | 4 | 0 | 186.73 | 20.5 | 210.5 |
| 5 | UCF | 4 | 124 | 78 | 62.9 | 898 | 7.2 | 6 | 2 | 136.47 | 31.0 | 224.5 |
| 6 | Memphis | 6 | 201 | 128 | 63.7 | 1359 | 6.8 | 9 | 5 | 130.27 | 33.5 | 226.5 |
| 7 | East Carolina | 5 | 143 | 92 | 64.3 | 1148 | 8.0 | 7 | 5 | 140.94 | 28.6 | 229.6 |
| 8 | Navy | 8 | 218 | 153 | 70.2 | 2069 | 9.5 | 12 | 5 | 163.48 | 27.3 | 258.6 |
| 9 | South Florida | 10 | 310 | 213 | 68.7 | 2729 | 8.8 | 24 | 8 | 163.05 | 31.0 | 272.9 |
| 10 | Tulane | 10 | 339 | 231 | 68.1 | 2897 | 8.5 | 25 | 7 | 160.14 | 33.9 | 289.7 |
| 11 | SMU | 4 | 155 | 101 | 65.2 | 1383 | 8.9 | 13 | 3 | 163.92 | 38.8 | 345.8 |