2021 American Athletic Conference Leaders Scoring Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 17 | 8 | 14 | 1 | 0 | 142 | 17.8 |
| 2 | Houston | 5 | 19 | 4 | 18 | 0 | 0 | 144 | 28.8 |
| 3 | Navy | 10 | 36 | 11 | 33 | 2 | 2 | 290 | 29.0 |
| 4 | Memphis | 7 | 26 | 8 | 23 | 1 | 0 | 205 | 29.3 |
| 5 | East Carolina | 6 | 22 | 8 | 21 | 0 | 0 | 177 | 29.5 |
| 6 | Tulsa | 5 | 23 | 4 | 23 | 0 | 0 | 173 | 34.6 |
| 7 | South Florida | 8 | 39 | 9 | 35 | 0 | 1 | 298 | 37.3 |
| 8 | Tulane | 9 | 44 | 12 | 41 | 0 | 0 | 341 | 37.9 |
| 9 | SMU | 4 | 20 | 5 | 19 | 0 | 0 | 154 | 38.5 |
| 10 | UCF | 4 | 20 | 6 | 20 | 0 | 0 | 158 | 39.5 |
| 11 | Temple | 5 | 30 | 6 | 29 | 0 | 0 | 227 | 45.4 |