2021 American Athletic Conference Leaders Scoring Defense - Games in August/September Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 3 | 6 | 1 | 6 | 0 | 0 | 45 | 15.0 |
| 2 | Houston | 4 | 8 | 3 | 8 | 0 | 0 | 65 | 16.3 |
| 3 | SMU | 4 | 11 | 6 | 8 | 0 | 0 | 92 | 23.0 |
| 4 | UCF | 3 | 12 | 1 | 12 | 0 | 0 | 87 | 29.0 |
| 5 | East Carolina | 4 | 15 | 5 | 14 | 0 | 0 | 119 | 29.8 |
| 6 | Temple | 4 | 16 | 2 | 16 | 0 | 1 | 120 | 30.0 |
| 7 | Tulsa | 4 | 14 | 8 | 14 | 0 | 0 | 122 | 30.5 |
| 8 | Memphis | 4 | 16 | 6 | 13 | 0 | 0 | 127 | 31.8 |
| 9 | Navy | 3 | 14 | 0 | 14 | 0 | 1 | 100 | 33.3 |
| 10 | South Florida | 4 | 19 | 2 | 19 | 0 | 0 | 139 | 34.8 |
| 11 | Tulane | 4 | 20 | 4 | 17 | 0 | 0 | 149 | 37.3 |