2021 American Athletic Conference Leaders Scoring Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 3 | 7 | 4 | 6 | 0 | 0 | 60 | 20.0 |
| 2 | Navy | 3 | 11 | 3 | 10 | 1 | 1 | 89 | 29.7 |
| 3 | Memphis | 1 | 4 | 1 | 4 | 0 | 0 | 31 | 31.0 |
| 4 | East Carolina | 2 | 9 | 1 | 9 | 0 | 0 | 66 | 33.0 |
| 5 | Houston | 1 | 5 | 0 | 5 | 0 | 0 | 35 | 35.0 |
| 6 | Tulsa | 4 | 19 | 3 | 19 | 0 | 0 | 142 | 35.5 |
| 7 | Tulane | 4 | 22 | 7 | 19 | 0 | 0 | 172 | 43.0 |
| 8 | Temple | 2 | 12 | 2 | 11 | 0 | 0 | 89 | 44.5 |
| 9 | South Florida | 4 | 24 | 3 | 24 | 0 | 1 | 179 | 44.8 |
| 10 | SMU | 2 | 12 | 3 | 11 | 0 | 0 | 92 | 46.0 |
| 11 | UCF | 1 | 8 | 0 | 8 | 0 | 0 | 56 | 56.0 |