2021 American Athletic Conference Leaders Scoring Defense - Games Lost Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 1 | 3 | 2 | 3 | 0 | 0 | 27 | 27.0 |
| 2 | East Carolina | 5 | 17 | 7 | 16 | 0 | 0 | 139 | 27.8 |
| 3 | Tulsa | 6 | 22 | 9 | 22 | 0 | 0 | 181 | 30.2 |
| 4 | Memphis | 6 | 23 | 8 | 23 | 0 | 0 | 185 | 30.8 |
| 5 | Navy | 8 | 34 | 7 | 32 | 2 | 2 | 265 | 33.1 |
| 6 | Houston | 2 | 10 | 1 | 10 | 0 | 0 | 73 | 36.5 |
| 7 | Tulane | 10 | 48 | 14 | 44 | 0 | 0 | 374 | 37.4 |
| 8 | SMU | 4 | 20 | 5 | 19 | 0 | 0 | 154 | 38.5 |
| 8 | South Florida | 10 | 51 | 10 | 47 | 0 | 1 | 385 | 38.5 |
| 10 | Temple | 9 | 51 | 10 | 50 | 0 | 1 | 388 | 43.1 |
| 11 | UCF | 4 | 25 | 4 | 25 | 0 | 0 | 187 | 46.8 |