2021 American Athletic Conference Leaders Passing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 11 | 313 | 166 | 53.0 | 1681 | 5.4 | 7 | 15 | 95.96 | 28.5 | 152.8 |
| 2 | Houston | 13 | 396 | 217 | 54.8 | 2526 | 6.4 | 15 | 14 | 113.81 | 30.5 | 194.3 |
| 3 | East Carolina | 10 | 321 | 189 | 58.9 | 2312 | 7.2 | 13 | 13 | 124.65 | 32.1 | 231.2 |
| 4 | UCF | 12 | 444 | 256 | 57.7 | 2591 | 5.8 | 11 | 11 | 109.90 | 37.0 | 215.9 |
| 5 | SMU | 10 | 336 | 191 | 56.8 | 2630 | 7.8 | 18 | 10 | 134.33 | 33.6 | 263.0 |
| 6 | South Florida | 8 | 263 | 161 | 61.2 | 1934 | 7.4 | 16 | 8 | 136.99 | 32.9 | 241.8 |
| 7 | Tulsa | 9 | 303 | 176 | 58.1 | 2064 | 6.8 | 8 | 7 | 119.40 | 33.7 | 229.3 |
| 7 | Memphis | 11 | 403 | 257 | 63.8 | 2747 | 6.8 | 21 | 7 | 134.75 | 36.6 | 249.7 |
| 7 | Tulane | 8 | 268 | 174 | 64.9 | 2091 | 7.8 | 18 | 7 | 147.41 | 33.5 | 261.4 |
| 10 | Temple | 10 | 238 | 141 | 59.2 | 1643 | 6.9 | 20 | 6 | 139.92 | 23.8 | 164.3 |
| 10 | Navy | 9 | 215 | 140 | 65.1 | 1905 | 8.9 | 11 | 6 | 150.84 | 23.9 | 211.7 |