2021 American Athletic Conference Leaders Passing Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 13 | 384 | 206 | 53.6 | 2220 | 5.8 | 13 | 16 | 105.05 | 29.5 | 170.8 |
| 2 | Houston | 13 | 401 | 223 | 55.6 | 2667 | 6.7 | 18 | 14 | 119.31 | 30.8 | 205.2 |
| 2 | East Carolina | 11 | 317 | 187 | 59.0 | 2392 | 7.5 | 15 | 14 | 129.17 | 28.8 | 217.5 |
| 4 | Tulsa | 12 | 370 | 212 | 57.3 | 2646 | 7.2 | 14 | 11 | 123.91 | 30.8 | 220.5 |
| 5 | UCF | 12 | 416 | 240 | 57.7 | 2476 | 6.0 | 10 | 10 | 110.81 | 34.7 | 206.3 |
| 5 | South Florida | 11 | 331 | 225 | 68.0 | 2912 | 8.8 | 25 | 10 | 160.76 | 30.1 | 264.7 |
| 7 | Memphis | 11 | 402 | 258 | 64.2 | 2812 | 7.0 | 21 | 8 | 136.20 | 36.5 | 255.6 |
| 7 | Tulane | 11 | 375 | 251 | 66.9 | 3071 | 8.2 | 25 | 8 | 153.45 | 34.1 | 279.2 |
| 9 | Navy | 12 | 306 | 204 | 66.7 | 2618 | 8.6 | 15 | 7 | 150.14 | 25.5 | 218.2 |
| 9 | SMU | 11 | 368 | 224 | 60.9 | 3124 | 8.5 | 26 | 7 | 151.69 | 33.5 | 284.0 |
| 11 | Temple | 11 | 296 | 182 | 61.5 | 2099 | 7.1 | 25 | 5 | 145.54 | 26.9 | 190.8 |