2021 Mid-American Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 8 | 1267 | 1583 | 468 | 2850 | 6.09 | 356.3 |
| 2 | Toledo | 8 | 1299 | 1635 | 584 | 2934 | 5.02 | 366.8 |
| 3 | Miami (Ohio) | 8 | 964 | 2080 | 554 | 3044 | 5.49 | 380.5 |
| 4 | Bowling Green | 8 | 1558 | 1642 | 561 | 3200 | 5.70 | 400.0 |
| 5 | Central Michigan | 8 | 1147 | 2088 | 584 | 3235 | 5.54 | 404.4 |
| 6 | Ball State | 8 | 1334 | 2018 | 580 | 3352 | 5.78 | 419.0 |
| 7 | Ohio | 8 | 1182 | 2237 | 570 | 3419 | 6.00 | 427.4 |
| 8 | Buffalo | 8 | 1672 | 1823 | 530 | 3495 | 6.59 | 436.9 |
| 9 | Eastern Michigan | 8 | 1588 | 1925 | 567 | 3513 | 6.20 | 439.1 |
| 10 | Northern Illinois | 9 | 1844 | 2257 | 603 | 4101 | 6.80 | 455.7 |
| 11 | Kent State | 9 | 1682 | 2563 | 710 | 4245 | 5.98 | 471.7 |
| 12 | Akron | 8 | 2228 | 1568 | 550 | 3796 | 6.90 | 474.5 |