2021 Mid-American Conference Leaders Total Defense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 6 | 1000 | 1421 | 465 | 2421 | 5.21 | 403.5 |
| 2 | Western Michigan | 5 | 995 | 1080 | 300 | 2075 | 6.92 | 415.0 |
| 3 | Bowling Green | 8 | 1661 | 1663 | 581 | 3324 | 5.72 | 415.5 |
| 4 | Miami (Ohio) | 6 | 1284 | 1241 | 403 | 2525 | 6.27 | 420.8 |
| 5 | Ohio | 9 | 2029 | 1804 | 637 | 3833 | 6.02 | 425.9 |
| 6 | Eastern Michigan | 6 | 1528 | 1138 | 426 | 2666 | 6.26 | 444.3 |
| 7 | Ball State | 7 | 1570 | 1561 | 482 | 3131 | 6.50 | 447.3 |
| 8 | Buffalo | 8 | 1615 | 2201 | 534 | 3816 | 7.15 | 477.0 |
| 9 | Central Michigan | 4 | 654 | 1358 | 284 | 2012 | 7.08 | 503.0 |
| 10 | Akron | 10 | 2851 | 2248 | 658 | 5099 | 7.75 | 509.9 |
| 11 | Kent State | 7 | 1890 | 1708 | 512 | 3598 | 7.03 | 514.0 |
| 12 | Northern Illinois | 5 | 1421 | 1412 | 339 | 2833 | 8.36 | 566.6 |