2021 Mid-American Conference Leaders Total Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 5 | 619 | 840 | 273 | 1459 | 5.34 | 291.8 |
| 2 | Bowling Green | 4 | 696 | 592 | 289 | 1288 | 4.46 | 322.0 |
| 3 | Toledo | 5 | 670 | 948 | 349 | 1618 | 4.64 | 323.6 |
| 4 | Central Michigan | 5 | 404 | 1334 | 305 | 1738 | 5.70 | 347.6 |
| 5 | Miami (Ohio) | 5 | 933 | 813 | 311 | 1746 | 5.61 | 349.2 |
| 6 | Buffalo | 4 | 667 | 828 | 257 | 1495 | 5.82 | 373.8 |
| 7 | Ball State | 5 | 959 | 1092 | 346 | 2051 | 5.93 | 410.2 |
| 8 | Eastern Michigan | 5 | 1011 | 1145 | 335 | 2156 | 6.44 | 431.2 |
| 9 | Ohio | 4 | 1134 | 634 | 295 | 1768 | 5.99 | 442.0 |
| 10 | Northern Illinois | 5 | 1159 | 1075 | 322 | 2234 | 6.94 | 446.8 |
| 11 | Akron | 4 | 759 | 1054 | 233 | 1813 | 7.78 | 453.3 |
| 12 | Kent State | 5 | 1200 | 1161 | 356 | 2361 | 6.63 | 472.2 |