2021 Mid-American Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 7 | 885 | 1418 | 502 | 2303 | 4.59 | 329.0 |
| 2 | Western Michigan | 7 | 1377 | 1239 | 394 | 2616 | 6.64 | 373.7 |
| 3 | Bowling Green | 6 | 1435 | 879 | 452 | 2314 | 5.12 | 385.7 |
| 4 | Miami (Ohio) | 8 | 1473 | 1696 | 532 | 3169 | 5.96 | 396.1 |
| 5 | Central Michigan | 7 | 979 | 1870 | 490 | 2849 | 5.81 | 407.0 |
| 6 | Ohio | 6 | 1133 | 1421 | 450 | 2554 | 5.68 | 425.7 |
| 7 | Ball State | 7 | 1179 | 1851 | 504 | 3030 | 6.01 | 432.9 |
| 8 | Buffalo | 6 | 1120 | 1526 | 421 | 2646 | 6.29 | 441.0 |
| 9 | Eastern Michigan | 7 | 1613 | 1667 | 505 | 3280 | 6.50 | 468.6 |
| 10 | Kent State | 9 | 2102 | 2141 | 644 | 4243 | 6.59 | 471.4 |
| 11 | Northern Illinois | 8 | 1944 | 1926 | 533 | 3870 | 7.26 | 483.8 |
| 12 | Akron | 6 | 1502 | 1686 | 397 | 3188 | 8.03 | 531.3 |