2021 Mid-American Conference Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 4 | 559 | 701 | 270 | 1260 | 4.67 | 315.0 |
| 2 | Western Michigan | 4 | 512 | 837 | 240 | 1349 | 5.62 | 337.3 |
| 3 | Miami (Ohio) | 4 | 268 | 1102 | 268 | 1370 | 5.11 | 342.5 |
| 4 | Ball State | 4 | 504 | 897 | 300 | 1401 | 4.67 | 350.3 |
| 5 | Eastern Michigan | 4 | 698 | 820 | 286 | 1518 | 5.31 | 379.5 |
| 6 | Northern Illinois | 4 | 523 | 1113 | 257 | 1636 | 6.37 | 409.0 |
| 7 | Ohio | 4 | 662 | 986 | 280 | 1648 | 5.89 | 412.0 |
| 8 | Bowling Green | 5 | 1050 | 1042 | 385 | 2092 | 5.43 | 418.4 |
| 9 | Central Michigan | 4 | 680 | 1099 | 294 | 1779 | 6.05 | 444.8 |
| 9 | Buffalo | 5 | 1125 | 1099 | 327 | 2224 | 6.80 | 444.8 |
| 11 | Akron | 4 | 981 | 799 | 268 | 1780 | 6.64 | 445.0 |
| 12 | Kent State | 4 | 843 | 1129 | 321 | 1972 | 6.14 | 493.0 |