2021 Big 12 Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 11 | 16 | 39 | 55 | 5.00 |
| 2 | Texas Tech | 10 | 5 | 37 | 42 | 4.20 |
| 3 | Oklahoma State | 10 | 7 | 31 | 38 | 3.80 |
| 4 | Iowa State | 11 | 8 | 29 | 37 | 3.36 |
| 5 | Texas | 10 | 7 | 28 | 35 | 3.50 |
| 6 | West Virginia | 12 | 9 | 25 | 34 | 2.83 |
| 7 | Oklahoma | 11 | 10 | 22 | 32 | 2.91 |
| 8 | TCU | 10 | 6 | 25 | 31 | 3.10 |
| 8 | Kansas State | 11 | 9 | 22 | 31 | 2.82 |
| 10 | Kansas | 10 | 7 | 16 | 23 | 2.30 |