2021 Big 12 Conference Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 41 | 55 | 9 | 105 | 26.3 |
| 2 | Oklahoma | 3 | 25 | 33 | 7 | 65 | 21.7 |
| 3 | Iowa State | 5 | 28 | 64 | 13 | 105 | 21.0 |
| 4 | TCU | 3 | 22 | 36 | 3 | 61 | 20.3 |
| 5 | Texas | 5 | 34 | 52 | 4 | 90 | 18.0 |
| 6 | West Virginia | 3 | 20 | 26 | 7 | 53 | 17.7 |
| 7 | Baylor | 5 | 48 | 27 | 7 | 82 | 16.4 |
| 8 | Texas Tech | 4 | 20 | 33 | 10 | 63 | 15.8 |
| 9 | Kansas State | 3 | 17 | 26 | 4 | 47 | 15.7 |
| 10 | Kansas | 3 | 16 | 19 | 3 | 38 | 12.7 |