2021 Big 12 Conference Leaders First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Iowa State | 1 | 11 | 15 | 1 | 27 | 27.0 |
| 2 | Texas | 2 | 26 | 20 | 2 | 48 | 24.0 |
| 2 | Oklahoma | 1 | 7 | 15 | 2 | 24 | 24.0 |
| 4 | Texas Tech | 2 | 17 | 24 | 5 | 46 | 23.0 |
| 5 | Oklahoma State | 3 | 32 | 32 | 4 | 68 | 22.7 |
| 6 | Baylor | 2 | 27 | 17 | 0 | 44 | 22.0 |
| 7 | Kansas State | 1 | 14 | 6 | 1 | 21 | 21.0 |
| 8 | TCU | 1 | 6 | 13 | 1 | 20 | 20.0 |
| 9 | Kansas | 1 | 7 | 8 | 1 | 16 | 16.0 |