2021 Big 12 Conference Leaders First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 4 | 36 | 52 | 10 | 98 | 24.5 |
| 2 | Oklahoma State | 4 | 43 | 43 | 10 | 96 | 24.0 |
| 3 | Oklahoma | 5 | 44 | 66 | 7 | 117 | 23.4 |
| 4 | Texas Tech | 5 | 45 | 53 | 6 | 104 | 20.8 |
| 5 | TCU | 5 | 47 | 45 | 6 | 98 | 19.6 |
| 6 | Texas | 4 | 34 | 39 | 5 | 78 | 19.5 |
| 6 | Iowa State | 4 | 32 | 42 | 4 | 78 | 19.5 |
| 8 | Kansas State | 4 | 29 | 44 | 4 | 77 | 19.3 |
| 9 | Baylor | 4 | 34 | 38 | 3 | 75 | 18.8 |
| 10 | Kansas | 4 | 30 | 33 | 2 | 65 | 16.3 |