2021 Big 12 Conference Leaders First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 7 | 66 | 76 | 18 | 160 | 22.9 |
| 2 | Iowa State | 7 | 51 | 90 | 13 | 154 | 22.0 |
| 3 | Oklahoma | 6 | 58 | 64 | 9 | 131 | 21.8 |
| 4 | West Virginia | 7 | 58 | 73 | 11 | 142 | 20.3 |
| 5 | Texas Tech | 7 | 60 | 72 | 7 | 139 | 19.9 |
| 6 | Baylor | 7 | 71 | 50 | 5 | 126 | 18.0 |
| 7 | Kansas | 6 | 49 | 51 | 5 | 105 | 17.5 |
| 8 | Texas | 6 | 49 | 49 | 6 | 104 | 17.3 |
| 9 | Kansas State | 6 | 45 | 51 | 7 | 103 | 17.2 |
| 9 | TCU | 5 | 46 | 37 | 3 | 86 | 17.2 |