2021 Big 12 Conference Leaders First Downs - Games in August/September Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 31 | 37 | 9 | 77 | 25.7 |
| 2 | Baylor | 4 | 61 | 37 | 1 | 99 | 24.8 |
| 3 | Oklahoma | 4 | 33 | 55 | 6 | 94 | 23.5 |
| 4 | Texas | 4 | 50 | 37 | 5 | 92 | 23.0 |
| 4 | Iowa State | 4 | 33 | 51 | 8 | 92 | 23.0 |
| 6 | West Virginia | 4 | 32 | 46 | 5 | 83 | 20.8 |
| 7 | Texas Tech | 4 | 31 | 40 | 6 | 77 | 19.3 |
| 8 | Oklahoma State | 4 | 29 | 39 | 7 | 75 | 18.8 |
| 9 | Kansas State | 4 | 43 | 26 | 4 | 73 | 18.3 |
| 10 | Kansas | 4 | 26 | 27 | 4 | 57 | 14.3 |