2021 Big 12 Conference Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 104 | 113 | 30 | 247 | 24.7 |
| 2 | Oklahoma | 11 | 92 | 127 | 17 | 236 | 21.5 |
| 2 | Iowa State | 11 | 76 | 140 | 20 | 236 | 21.5 |
| 4 | West Virginia | 12 | 94 | 134 | 21 | 249 | 20.8 |
| 5 | TCU | 10 | 100 | 92 | 14 | 206 | 20.6 |
| 6 | Texas | 10 | 94 | 94 | 11 | 199 | 19.9 |
| 7 | Texas Tech | 10 | 82 | 102 | 13 | 197 | 19.7 |
| 8 | Baylor | 11 | 108 | 92 | 12 | 212 | 19.3 |
| 9 | Kansas State | 11 | 80 | 96 | 13 | 189 | 17.2 |
| 10 | Kansas | 10 | 74 | 84 | 9 | 167 | 16.7 |