2021 American Athletic Conference Leaders Interceptions - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | South Florida | 8 | 7 | 134 | 1 | 0.88 |
| 2 | Cincinnati | 9 | 10 | 127 | 1 | 1.11 |
| 3 | Houston | 9 | 11 | 119 | 1 | 1.22 |
| 4 | East Carolina | 8 | 10 | 104 | 1 | 1.25 |
| 4 | UCF | 8 | 5 | 104 | 0 | 0.63 |
| 6 | Tulane | 8 | 5 | 82 | 0 | 0.63 |
| 7 | Tulsa | 8 | 7 | 60 | 0 | 0.88 |
| 8 | Temple | 8 | 3 | 45 | 0 | 0.38 |
| 9 | Memphis | 8 | 8 | 40 | 0 | 1.00 |
| 10 | SMU | 8 | 4 | 11 | 0 | 0.50 |
| 11 | Navy | 8 | 5 | 1 | 0 | 0.63 |