2021 American Athletic Conference Leaders Interceptions - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Houston | 11 | 14 | 210 | 2 | 1.27 |
| 2 | Cincinnati | 11 | 12 | 158 | 1 | 1.09 |
| 3 | South Florida | 9 | 7 | 134 | 1 | 0.78 |
| 4 | East Carolina | 10 | 13 | 124 | 1 | 1.30 |
| 5 | UCF | 10 | 9 | 114 | 0 | 0.90 |
| 6 | Tulane | 9 | 6 | 95 | 0 | 0.67 |
| 7 | SMU | 10 | 7 | 63 | 0 | 0.70 |
| 8 | Tulsa | 10 | 9 | 60 | 0 | 0.90 |
| 9 | Temple | 9 | 4 | 52 | 1 | 0.44 |
| 10 | Memphis | 10 | 8 | 40 | 0 | 0.80 |
| 11 | Navy | 12 | 7 | 23 | 0 | 0.58 |