2021 American Athletic Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | South Florida | 2 | 3 | 115 | 0 | 1.50 |
| 2 | Tulsa | 2 | 2 | 55 | 1 | 1.00 |
| 3 | Cincinnati | 2 | 4 | 43 | 0 | 2.00 |
| 4 | Tulane | 2 | 2 | 0 | 0 | 1.00 |
| 4 | East Carolina | 1 | 1 | 0 | 0 | 1.00 |
| 4 | UCF | 2 | 1 | 0 | 0 | 0.50 |
| 4 | Temple | 2 | 1 | 0 | 0 | 0.50 |