2021 American Athletic Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | South Florida | 4 | 2 | 88 | 0 | 0.50 |
| 2 | Tulsa | 4 | 4 | 55 | 1 | 1.00 |
| 3 | Cincinnati | 3 | 4 | 40 | 0 | 1.33 |
| 4 | Tulane | 4 | 3 | 33 | 0 | 0.75 |
| 5 | Memphis | 1 | 2 | 25 | 0 | 2.00 |
| 6 | Navy | 3 | 1 | 1 | 0 | 0.33 |
| 7 | East Carolina | 2 | 2 | 0 | 0 | 1.00 |