2021 American Athletic Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | South Florida | 4 | 3 | 115 | 0 | 0.75 |
| 2 | SMU | 4 | 6 | 109 | 0 | 1.50 |
| 3 | Houston | 4 | 3 | 91 | 1 | 0.75 |
| 4 | Tulane | 4 | 5 | 74 | 1 | 1.25 |
| 5 | Cincinnati | 3 | 6 | 56 | 0 | 2.00 |
| 6 | Tulsa | 4 | 3 | 55 | 1 | 0.75 |
| 7 | East Carolina | 4 | 5 | 43 | 1 | 1.25 |
| 8 | Navy | 3 | 2 | 22 | 0 | 0.67 |
| 9 | Temple | 4 | 3 | 11 | 1 | 0.75 |
| 10 | Memphis | 4 | 1 | 1 | 0 | 0.25 |
| 11 | UCF | 3 | 3 | 0 | 0 | 1.00 |