2021 Big 12 Conference Leaders Passes Defended - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 6 | 23 | 29 | 7.25 |
| 2 | Baylor | 4 | 6 | 16 | 22 | 5.50 |
| 3 | Kansas State | 4 | 6 | 12 | 18 | 4.50 |
| 3 | Oklahoma State | 4 | 2 | 16 | 18 | 4.50 |
| 5 | Iowa State | 4 | 4 | 7 | 11 | 2.75 |
| 6 | West Virginia | 4 | 1 | 9 | 10 | 2.50 |
| 7 | TCU | 3 | 4 | 4 | 8 | 2.67 |
| 7 | Kansas | 3 | 1 | 7 | 8 | 2.67 |
| 9 | Texas | 3 | 1 | 6 | 7 | 2.33 |
| 10 | Oklahoma | 4 | 3 | 3 | 6 | 1.50 |