2021 Big 12 Conference Leaders Passes Defended - Games Won Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 12 | 16 | 40 | 56 | 4.67 |
| 2 | Oklahoma State | 12 | 9 | 45 | 54 | 4.50 |
| 3 | Texas Tech | 7 | 9 | 35 | 44 | 6.29 |
| 4 | Kansas State | 8 | 9 | 26 | 35 | 4.38 |
| 5 | Oklahoma | 11 | 8 | 17 | 25 | 2.27 |
| 6 | TCU | 5 | 5 | 15 | 20 | 4.00 |
| 7 | Iowa State | 7 | 6 | 12 | 18 | 2.57 |
| 8 | West Virginia | 6 | 5 | 11 | 16 | 2.67 |
| 9 | Kansas | 2 | 2 | 6 | 8 | 4.00 |
| 10 | Texas | 5 | 2 | 4 | 6 | 1.20 |