2021 Big 12 Conference Leaders Passes Defended - Games Lost Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas | 7 | 5 | 27 | 32 | 4.57 |
| 2 | Iowa State | 6 | 5 | 19 | 24 | 4.00 |
| 3 | Kansas | 10 | 5 | 17 | 22 | 2.20 |
| 4 | West Virginia | 7 | 4 | 17 | 21 | 3.00 |
| 5 | Texas Tech | 6 | 1 | 18 | 19 | 3.17 |
| 6 | TCU | 7 | 5 | 12 | 17 | 2.43 |
| 7 | Baylor | 2 | 3 | 8 | 11 | 5.50 |
| 8 | Oklahoma | 2 | 3 | 7 | 10 | 5.00 |
| 9 | Kansas State | 5 | 2 | 4 | 6 | 1.20 |
| 10 | Oklahoma State | 2 | 0 | 2 | 2 | 1.00 |