2021 Big 12 Conference Leaders Passes Defended - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 9 | 3 | 39 | 42 | 4.67 |
| 2 | Texas Tech | 7 | 7 | 31 | 38 | 5.43 |
| 3 | Baylor | 8 | 14 | 23 | 37 | 4.63 |
| 4 | Oklahoma | 6 | 8 | 17 | 25 | 4.17 |
| 4 | Texas | 8 | 7 | 18 | 25 | 3.13 |
| 6 | West Virginia | 8 | 4 | 20 | 24 | 3.00 |
| 7 | TCU | 7 | 7 | 16 | 23 | 3.29 |
| 8 | Iowa State | 7 | 4 | 14 | 18 | 2.57 |
| 9 | Kansas | 7 | 2 | 15 | 17 | 2.43 |
| 10 | Kansas State | 6 | 3 | 8 | 11 | 1.83 |