2021 Big 12 Conference Leaders Passes Defended - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Baylor | 7 | 14 | 28 | 42 | 6.00 |
| 2 | Texas Tech | 7 | 7 | 26 | 33 | 4.71 |
| 3 | Oklahoma State | 7 | 5 | 22 | 27 | 3.86 |
| 4 | Iowa State | 7 | 7 | 19 | 26 | 3.71 |
| 5 | Texas | 6 | 4 | 20 | 24 | 4.00 |
| 6 | West Virginia | 7 | 6 | 17 | 23 | 3.29 |
| 7 | TCU | 5 | 2 | 15 | 17 | 3.40 |
| 7 | Kansas State | 6 | 6 | 11 | 17 | 2.83 |
| 9 | Oklahoma | 6 | 4 | 12 | 16 | 2.67 |
| 10 | Kansas | 6 | 4 | 8 | 12 | 2.00 |