2021 Big 12 Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 9 | 6 | 36 | 42 | 4.67 |
| 2 | Kansas State | 10 | 10 | 28 | 38 | 3.80 |
| 3 | Baylor | 9 | 7 | 30 | 37 | 4.11 |
| 4 | Oklahoma State | 10 | 8 | 25 | 33 | 3.30 |
| 5 | Iowa State | 8 | 9 | 22 | 31 | 3.88 |
| 5 | TCU | 9 | 8 | 23 | 31 | 3.44 |
| 7 | West Virginia | 10 | 7 | 19 | 26 | 2.60 |
| 8 | Kansas | 9 | 6 | 18 | 24 | 2.67 |
| 9 | Oklahoma | 10 | 7 | 16 | 23 | 2.30 |
| 10 | Texas | 7 | 2 | 17 | 19 | 2.71 |