2021 Big 12 Conference Leaders Passes Defended - Games in November Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 3 | 2 | 16 | 18 | 6.00 |
| 1 | Oklahoma State | 4 | 1 | 17 | 18 | 4.50 |
| 3 | Iowa State | 4 | 3 | 13 | 16 | 4.00 |
| 4 | Baylor | 4 | 3 | 12 | 15 | 3.75 |
| 5 | Kansas State | 4 | 3 | 11 | 14 | 3.50 |
| 5 | Texas | 4 | 0 | 14 | 14 | 3.50 |
| 7 | Oklahoma | 3 | 5 | 8 | 13 | 4.33 |
| 7 | TCU | 4 | 3 | 10 | 13 | 3.25 |
| 9 | Kansas | 4 | 4 | 7 | 11 | 2.75 |
| 10 | West Virginia | 4 | 4 | 5 | 9 | 2.25 |