2021 American Athletic Conference Leaders Passes Defended - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | East Carolina | 8 | 10 | 28 | 38 | 4.75 |
| 1 | Houston | 9 | 11 | 27 | 38 | 4.22 |
| 3 | Cincinnati | 9 | 10 | 27 | 37 | 4.11 |
| 4 | UCF | 8 | 5 | 31 | 36 | 4.50 |
| 5 | Tulsa | 8 | 7 | 28 | 35 | 4.38 |
| 6 | Memphis | 8 | 8 | 26 | 34 | 4.25 |
| 7 | Tulane | 8 | 5 | 24 | 29 | 3.63 |
| 7 | SMU | 8 | 4 | 25 | 29 | 3.63 |
| 9 | Temple | 8 | 3 | 25 | 28 | 3.50 |
| 10 | South Florida | 8 | 7 | 17 | 24 | 3.00 |
| 11 | Navy | 8 | 5 | 15 | 20 | 2.50 |