2021 American Athletic Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | UCF | 12 | 11 | 56 | 67 | 5.58 |
| 2 | East Carolina | 10 | 13 | 43 | 56 | 5.60 |
| 3 | Memphis | 11 | 7 | 48 | 55 | 5.00 |
| 3 | Houston | 13 | 14 | 41 | 55 | 4.23 |
| 5 | Cincinnati | 11 | 15 | 39 | 54 | 4.91 |
| 6 | Tulsa | 9 | 7 | 37 | 44 | 4.89 |
| 7 | SMU | 10 | 10 | 31 | 41 | 4.10 |
| 8 | Temple | 10 | 6 | 24 | 30 | 3.00 |
| 9 | South Florida | 8 | 8 | 21 | 29 | 3.63 |
| 10 | Navy | 9 | 6 | 22 | 28 | 3.11 |
| 11 | Tulane | 8 | 7 | 19 | 26 | 3.25 |